degarelix for the treatment of advanced prostate cancer compared with gnrh-agonists: a systematic review and meta-analysis

نویسندگان

seyed alireza hosseini food and drug research center, clinical trials group, iran food and drug administration, tehran, iran.

fatemeh rajabi community based participatory research center, iranian institute for reduction of high-risk behaviors, & center for academic and health policy, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

ali akbari sari department of health management and economics, school of public health, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

mohsen ayati department of urology, imam khomeini hospital, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

چکیده

background: hormone therapy is currently the mainstay in the management of locally advanced and metastatic prostate cancer. we performed a systematic review to compare safety, efficacy and effectiveness of degarelix, a new gonadotropin-releasing hormone (gnrh) antagonist (blocker), versus gonadotropin-releasing hormone (gnrh) agonists. methods: medline, web of science and the cochrane library were searched to identify all of the published randomized controlled trials (rcts) that used degarelix versus gonadotropin-releasing hormone agonists with or without anti-androgen therapy for the treatment of prostate cancer. we performed meta-analysis of extracted data on safety and efficacy of the target medication. results: six studies were included. they involved a total of 2296 patients which were used in the meta-analysis. follow-up times after treatment were between 12 weeks and 12 months. three of six rcts compared degarelix with goserelin and the others compared it with leuprolide.meta-analysis on safety outcomes revealed that the only statistically significant difference between the degarelix treated group and gnrh agonists treated group was complication in the injection site which was higher in degarelix-treated group (or= 46.34, 95% ci: 15.79 to 136, p< 0.001). although general mortality rate was lower in degarelix-treated group (or= 2.06, 95% ci: 1.08 to 3.93, p=0.03) mortality due to the drug side effects was not different. meta-analysis of efficacy data also showed that international prostate symptom score (ipss) reduction at week 12, (md=-1.85, 95% ci: -2.97 to -0.72, p=0.001) and testosterone reduction between day 1-28, (or=11.58, 95% ci: 5.77 to 23.22, p< 0.001) was statistically higher in degarelix-treated group. testosterone reduction after day 28 and prostate volume reduction did not have significant difference. conclusion: our meta-analysis indicates that, compared with gnrh agonists, degarelix has significantly more effects on lower urinary tract symptoms and also prostate specific antigen (psa) and testosterone reduction in the first month of the treatment. except minor complications in the injection site like pain, erythema and swelling, there is no increase in major side effects and mortality due to degarelix. this is while the effect on testosterone and psa after the first month of treatment is not statistically different between the two groups.

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Degarelix for the treatment of advanced prostate cancer compared with GnRh-Agonists: a systematic review and meta-analysis

Background: Hormone therapy is currently the mainstay in the management of locally advanced and metastatic prostate cancer. We performed a systematic review to compare safety, efficacy and effectiveness of degarelix, a new gonadotropin-releasing hormone (GnRH) antagonist (blocker), versus gonadotropin-releasing hormone (GnRH) agonists. Methods: MEDLINE, Web of Science and the Cochrane librar...

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عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۳۰، شماره ۱، صفحات ۴۴-۵۷

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